Survival of Parkinson's disease patients in a large prospective cohort of male health professionals
Identifieur interne : 001190 ( Main/Exploration ); précédent : 001189; suivant : 001191Survival of Parkinson's disease patients in a large prospective cohort of male health professionals
Auteurs : Honglei Chen [États-Unis] ; Shumin M. Zhang [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Miguel A. Hernán [États-Unis] ; Alberto Ascherio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
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Abstract
Parkinson's disease (PD) patients have higher mortality than individuals without PD. However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20881
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1002">1002</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">111017AF10D36762A15A4C8D7E1FDB288A72D2EB</idno><idno type="DOI">10.1002/mds.20881</idno><idno type="ArticleID">MDS20881</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>disease duration</term><term>morality</term><term>smoking</term><term>survival</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients have higher mortality than individuals without PD. However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name></region><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><name sortKey="Hernan, Miguel A" sort="Hernan, Miguel A" uniqKey="Hernan M" first="Miguel A." last="Hernán">Miguel A. Hernán</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><name sortKey="Zhang, Shumin M" sort="Zhang, Shumin M" uniqKey="Zhang S" first="Shumin M." last="Zhang">Shumin M. Zhang</name><name sortKey="Zhang, Shumin M" sort="Zhang, Shumin M" uniqKey="Zhang S" first="Shumin M." last="Zhang">Shumin M. Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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